In silico, in vitro and cellular analysis with a kinome-wide inhibitor panel correlates cellular LRRK2 dephosphorylation to inhibitor activity on LRRK2

In silico, in vitro and cellular analysis with a kinome-wide inhibitor panel correlates cellular LRRK2 dephosphorylation to inhibitor activity on LRRK2

Leucine-rich repeat kinase 2 (LRRK2) is a complex, multidomain protein which is considered a valuable target for potential disease-modifying therapeutic strategies for Parkinson’s disease. In mammalian cells and brain, LRRK2 is phosphorylated and treatment of cells with inhibitors of LRRK2 kinase ac...

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Bibliographic Details
Main Authors: Renee eVancraenenbroeck, Joren eDe Raeymaecker, Evy eLobbestael, Fangye eGao, Marc eDe Maeyer, Arnout eVoet, Veerle eBaekelandt, Jean-Marc eTaymans
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Phosphorylation
Parkinson’s disease
kinase
Docking
inhibitor
MOE
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2014.00051/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnmol.2014.00051/full

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