CLEC-2 Prevents Accumulation and Retention of Inflammatory Macrophages During Murine Peritonitis

CLEC-2 Prevents Accumulation and Retention of Inflammatory Macrophages During Murine Peritonitis

Platelets play a key role in the development, progression and resolution of the inflammatory response during sterile inflammation and infection, although the mechanism is not well understood. Here we show that platelet CLEC-2 reduces tissue inflammation by regulating inflammatory macrophage activati...

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Bibliographic Details
Main Authors: Joshua H. Bourne, Nonantzin Beristain-Covarrubias, Malou Zuidscherwoude, Joana Campos, Ying Di, Evelyn Garlick, Martina Colicchia, Lauren V. Terry, Steven G. Thomas, Alexander Brill, Jagadeesh Bayry, Steve P. Watson, Julie Rayes
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
CLEC-2
podoplanin
macrophage
inflammation
platelet
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.693974/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.693974/full

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