Cdc42-Interacting Protein 4 Represses E-Cadherin Expression by Promoting β-Catenin Translocation to the Nucleus in Murine Renal Tubular Epithelial Cells

Cdc42-Interacting Protein 4 Represses E-Cadherin Expression by Promoting β-Catenin Translocation to the Nucleus in Murine Renal Tubular Epithelial Cells

Renal fibrosis is an inevitable outcome of end-stage chronic kidney disease. During this process, epithelial cells lose E-cadherin expression. β-Catenin may act as a mediator by accumulation and translocation to the nucleus. Studies have suggested that CIP4, a Cdc42 effector protein, is associated...

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Bibliographic Details
Main Authors: Chuou Xu, Qiaodan Zhou, Lili Liu, Ping Liu, Guangchang Pei, Rui Zeng, Min Han, Gang Xu
Format: Article
Language:English
Published: MDPI AG 2015-08-01
Series:International Journal of Molecular Sciences
Subjects:
TGF-β1
CIP4
β-catenin
E-cadherin
renal tubular epithelial cells
Online Access:http://www.mdpi.com/1422-0067/16/8/19170

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http://www.mdpi.com/1422-0067/16/8/19170

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