Lycopene prevents lipid accumulation in hepatocytes by stimulating PPARα and improving mitochondrial function

Lycopene prevents lipid accumulation in hepatocytes by stimulating PPARα and improving mitochondrial function

The prevalence of nonalcoholic fatty liver disease (NAFLD) has increased over the decades. Lycopene (LYC), a major carotenoid present in tomato, has been previously demonstrated to possess liver-protecting and lipid-lowering bioactivities. However, the underlying mechanism of how LYC impact on the l...

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Main Authors: Jia Wang, Tonghui Geng, Qianhui Zou, Ningru Yang, Weiyang Zhao, Yitong Li, Xintong Tan, Tian Yuan, Xuebo Liu, Zhigang Liu
Format: Article
Language:English
Published: Elsevier 2020-04-01
Series:Journal of Functional Foods
Subjects:
Lycopene
Lipid metabolism dysfunction
Mitochondrial function
Nonalcoholic fatty liver disease
PPARα
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464620300815
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spelling doaj-b069b4a4c01043b3a8070638d5bad51a2021-04-30T07:18:31ZengElsevierJournal of Functional Foods1756-46462020-04-0167103857Lycopene prevents lipid accumulation in hepatocytes by stimulating PPARα and improving mitochondrial functionJia Wang0Tonghui Geng1Qianhui Zou2Ningru Yang3Weiyang Zhao4Yitong Li5Xintong Tan6Tian Yuan7Xuebo Liu8Zhigang Liu9Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi, China; Department of Nutrition and Food Hygiene, School of Public Health, Shanxi Medical University, Taiyuan, Shanxi, ChinaLaboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi, ChinaLaboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi, ChinaLaboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi, ChinaDepartment of Food Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, NY, United StatesDepartment of Food Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, NY, United StatesLaboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi, ChinaLaboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi, ChinaLaboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi, ChinaLaboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi, China; Department of Food Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, NY, United States; Corresponding author at: College of Food Science and Engineering, Northwest A&F University, Xinong Road 22, Yangling 712100, China.The prevalence of nonalcoholic fatty liver disease (NAFLD) has increased over the decades. Lycopene (LYC), a major carotenoid present in tomato, has been previously demonstrated to possess liver-protecting and lipid-lowering bioactivities. However, the underlying mechanism of how LYC impact on the lipid metabolism in the liver is elusive. Here, we found that LYC significantly suppressed lipid accumulation in palmitate- treated HepG2 hepatocytes cell line by stimulating PPARα expression and enhanced lipolysis consequently. It has also been revealed that LYC prevented palmitate-induced mitochondrial dysfunction by improving mitochondrial complex expression and activating mitochondrial biogenesis pathway AMPK/SIRT1/PGC1α. Moreover, in line with in vitro study, LYC treatment significantly suppressed lipid accumulation and enhanced PPARα expression in western diet-feeding mice liver. LYC also enhanced the expressions of mitochondrial complexes and antioxidant related enzymes HO-1/NQO1. In conclusion, the mediating effects of LYC on mitochondrial function and PPARα signaling might play pivotal roles in its beneficial effects on NAFLD.http://www.sciencedirect.com/science/article/pii/S1756464620300815LycopeneLipid metabolism dysfunctionMitochondrial functionNonalcoholic fatty liver diseasePPARα
collection DOAJ
language English
format Article
sources DOAJ
author Jia Wang
Tonghui Geng
Qianhui Zou
Ningru Yang
Weiyang Zhao
Yitong Li
Xintong Tan
Tian Yuan
Xuebo Liu
Zhigang Liu
spellingShingle Jia Wang
Tonghui Geng
Qianhui Zou
Ningru Yang
Weiyang Zhao
Yitong Li
Xintong Tan
Tian Yuan
Xuebo Liu
Zhigang Liu
Lycopene prevents lipid accumulation in hepatocytes by stimulating PPARα and improving mitochondrial function
Journal of Functional Foods
Lycopene
Lipid metabolism dysfunction
Mitochondrial function
Nonalcoholic fatty liver disease
PPARα
author_facet Jia Wang
Tonghui Geng
Qianhui Zou
Ningru Yang
Weiyang Zhao
Yitong Li
Xintong Tan
Tian Yuan
Xuebo Liu
Zhigang Liu
author_sort Jia Wang
title Lycopene prevents lipid accumulation in hepatocytes by stimulating PPARα and improving mitochondrial function
title_short Lycopene prevents lipid accumulation in hepatocytes by stimulating PPARα and improving mitochondrial function
title_full Lycopene prevents lipid accumulation in hepatocytes by stimulating PPARα and improving mitochondrial function
title_fullStr Lycopene prevents lipid accumulation in hepatocytes by stimulating PPARα and improving mitochondrial function
title_full_unstemmed Lycopene prevents lipid accumulation in hepatocytes by stimulating PPARα and improving mitochondrial function
title_sort lycopene prevents lipid accumulation in hepatocytes by stimulating pparα and improving mitochondrial function
publisher Elsevier
series Journal of Functional Foods
issn 1756-4646
publishDate 2020-04-01
description The prevalence of nonalcoholic fatty liver disease (NAFLD) has increased over the decades. Lycopene (LYC), a major carotenoid present in tomato, has been previously demonstrated to possess liver-protecting and lipid-lowering bioactivities. However, the underlying mechanism of how LYC impact on the lipid metabolism in the liver is elusive. Here, we found that LYC significantly suppressed lipid accumulation in palmitate- treated HepG2 hepatocytes cell line by stimulating PPARα expression and enhanced lipolysis consequently. It has also been revealed that LYC prevented palmitate-induced mitochondrial dysfunction by improving mitochondrial complex expression and activating mitochondrial biogenesis pathway AMPK/SIRT1/PGC1α. Moreover, in line with in vitro study, LYC treatment significantly suppressed lipid accumulation and enhanced PPARα expression in western diet-feeding mice liver. LYC also enhanced the expressions of mitochondrial complexes and antioxidant related enzymes HO-1/NQO1. In conclusion, the mediating effects of LYC on mitochondrial function and PPARα signaling might play pivotal roles in its beneficial effects on NAFLD.
topic Lycopene
Lipid metabolism dysfunction
Mitochondrial function
Nonalcoholic fatty liver disease
PPARα
url http://www.sciencedirect.com/science/article/pii/S1756464620300815
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