Synthesis of Thymidine Phosphorylase Inhibitor Based on Quinoxaline Derivatives and Their Molecular Docking Study

Synthesis of Thymidine Phosphorylase Inhibitor Based on Quinoxaline Derivatives and Their Molecular Docking Study

We have synthesized quinoxaline analogs (1–25), characterized by 1H-NMR and HREI-MS and evaluated for thymidine phosphorylase inhibition. Among the series, nineteen analogs showed better inhibition when compared with the standard inhibitor 7-Deazaxanthine (IC50 = 38.68 ± 4.42 &a...

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Bibliographic Details
Main Authors: Noor Barak Almandil, Muhammad Taha, Rai Khalid Farooq, Amani Alhibshi, Mohamed Ibrahim, El Hassane Anouar, Mohammed Gollapalli, Fazal Rahim, Muhammad Nawaz, Syed Adnan Ali Shah, Qamar Uddin Ahmed, Zainul Amiruddin Zakaria
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Molecules
Subjects:
quinoxaline analogs
synthesis
thymidine phosphorylase inhibition
molecular docking
Online Access:http://www.mdpi.com/1420-3049/24/6/1002

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http://www.mdpi.com/1420-3049/24/6/1002

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