An epigenetic and transcriptomic signature of immune tolerance in human monocytes through multi-omics integration

An epigenetic and transcriptomic signature of immune tolerance in human monocytes through multi-omics integration

Abstract Background The plasticity of monocytes enables them to exert multiple roles during an immune response, including promoting immune tolerance. How monocytes alter their functions to convey immune tolerance in the context of lower respiratory tract infections in humans is not well understood....

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Bibliographic Details
Main Authors: Xanthe Brands, Bastiaan W. Haak, Augustijn M. Klarenbeek, Joe Butler, Fabrice Uhel, Wanhai Qin, Natasja A. Otto, Marja E. Jakobs, Daniël R. Faber, René Lutter, W. Joost Wiersinga, Tom van der Poll, Brendon P. Scicluna
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Genome Medicine
Subjects:
Monocytes
Pneumonia
Immune tolerance
Cytokines
DNA methylation
Epigenetics
Online Access:https://doi.org/10.1186/s13073-021-00948-1

Internet

https://doi.org/10.1186/s13073-021-00948-1

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