Investigation of Efavirenz Discontinuation in Multi-ethnic Populations of HIV-positive Individuals by Genetic Analysis

Investigation of Efavirenz Discontinuation in Multi-ethnic Populations of HIV-positive Individuals by Genetic Analysis

Background: Efavirenz (EFV) based antiretroviral therapy is expanding worldwide. However discontinuation of EFV containing regimens is common in some patients, particularly black patients, due most often to neuropsychiatric side effects. These adverse drug effects often result in premature drug disc...

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Bibliographic Details
Main Authors: Nathan W. Cummins, Jacqueline Neuhaus, Haitao Chu, James Neaton, Christoph Wyen, Jürgen K. Rockstroh, Daniel J. Skiest, Mark A. Boyd, Saye Khoo, Margalida Rotger, Amalio Telenti, Richard Weinshilboum, Andrew D. Badley
Format: Article
Language:English
Published: Elsevier 2015-07-01
Series:EBioMedicine
Subjects:
HIV
Pharmacogenetics
Efavirenz
Premature discontinuation
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396415300190

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http://www.sciencedirect.com/science/article/pii/S2352396415300190

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