Pigment epithelium-derived factor protects retinal ganglion cells from hypoxia-induced apoptosis by preventing mitochondrial dysfunction

Pigment epithelium-derived factor protects retinal ganglion cells from hypoxia-induced apoptosis by preventing mitochondrial dysfunction

AIM: To investigate the potential of pigment epithelium-derived factor (PEDF) to protect the immortalized rat retinal ganglion cells-5 (RGC-5) exposed to CoCl2-induced chemical hypoxia. METHODS: After being differentiated with staurosporine (SS), RGC-5 cells were cultured in four conditions: contro...

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Bibliographic Details
Main Authors: Shu-Wei Tian, Yuan Ren, Jin-Zhi Pei, Bai-Chao Ren, Yuan He
Format: Article
Language:English
Published: Press of International Journal of Ophthalmology (IJO PRESS) 2017-07-01
Series:International Journal of Ophthalmology
Subjects:
1054
pigment epithelium-derived factor
CoCl2
retinal ganglion cells-5
reactive oxygen species
reduced glutathione hormone
mitochondrial permeability transition pores
membrane potential
adenosine triphosphate
Cyt C
apoptosis-inducing factor
Online Access:http://www.ijo.cn/en_publish/2017/7/20170705.pdf

Internet

http://www.ijo.cn/en_publish/2017/7/20170705.pdf

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