SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint

SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint

Histone modifications establish the chromatin states that coordinate the DNA damage response. In this study, we show that SETD2, the enzyme that trimethylates histone H3 lysine 36 (H3K36me3), is required for ATM activation upon DNA double-strand breaks (DSBs). Moreover, we find that SETD2 is necessa...

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Bibliographic Details
Main Authors: Sílvia Carvalho, Alexandra C Vítor, Sreerama C Sridhara, Filipa B Martins, Ana C Raposo, Joana MP Desterro, João Ferreira, Sérgio F de Almeida
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-05-01
Series:eLife
Subjects:
cancer
DNA damage response
p53-mediated checkpoint
SETD2
Online Access:https://elifesciences.org/articles/02482

Internet

https://elifesciences.org/articles/02482

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