Blockade of voltage-gated K+ currents in rat mesenteric arterial smooth muscle cells by MK801

Blockade of voltage-gated K+ currents in rat mesenteric arterial smooth muscle cells by MK801

MK801 (dizocilpine), a phencyclidine (PCP) derivative, is a potent noncompetitive antagonist of the N-Methyl-D-aspartate receptor (NMDAr). Another PCP derivative, ketamine, was reported to block voltage-gated K+ (Kv) channels, which was independent of NMDAr function. Kv currents are major regulators...

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Bibliographic Details
Main Authors: Jeong Min Kim, Sang Woong Park, Hai Yue Lin, Kyung Chul Shin, Dong Jun Sung, Jae Gon Kim, Hana Cho, Bokyung Kim, Young Min Bae
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Journal of Pharmacological Sciences
Subjects:
MK801
Voltage-gated K+ channels
Phencyclidine
Schizophrenia
Hypertension
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861314000127

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http://www.sciencedirect.com/science/article/pii/S1347861314000127

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