Anomalies in Dopamine Transporter Expression and Primary Cilium Distribution in the Dorsal Striatum of a Mouse Model of Niemann-Pick C1 Disease

Anomalies in Dopamine Transporter Expression and Primary Cilium Distribution in the Dorsal Striatum of a Mouse Model of Niemann-Pick C1 Disease

The Niemann-Pick type C1 (NPC1) is a rare genetic disease characterized by the accumulation of endocytosed cholesterol and other lipids in the endosome/lysosome compartments. In the brain, the accumulation/mislocalization of unesterified cholesterol, gangliosides and sphingolipids is responsible for...

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Bibliographic Details
Main Authors: Micaela Lucarelli, Chiara Di Pietro, Gina La Sala, Maria Teresa Fiorenza, Daniela Marazziti, Sonia Canterini
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Niemann-Pick C1
mouse model
striatum
primary cilium
dopamine
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00226/full

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https://www.frontiersin.org/article/10.3389/fncel.2019.00226/full

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