CSF1R-dependent macrophages control postnatal somatic growth and organ maturation.

CSF1R-dependent macrophages control postnatal somatic growth and organ maturation.

Homozygous mutation of the Csf1r locus (Csf1rko) in mice, rats and humans leads to multiple postnatal developmental abnormalities. To enable analysis of the mechanisms underlying the phenotypic impacts of Csf1r mutation, we bred a rat Csf1rko allele to the inbred dark agouti (DA) genetic background...

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Bibliographic Details
Main Authors: Sahar Keshvari, Melanie Caruso, Ngari Teakle, Lena Batoon, Anuj Sehgal, Omkar L Patkar, Michelle Ferrari-Cestari, Cameron E Snell, Chen Chen, Alex Stevenson, Felicity M Davis, Stephen J Bush, Clare Pridans, Kim M Summers, Allison R Pettit, Katharine M Irvine, David A Hume
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-06-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1009605

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https://doi.org/10.1371/journal.pgen.1009605

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