The rs11515 polymorphism is more frequent and associated with aggressive breast tumors with increased ANRIL and decreased p16INK4A expression

The rs11515 polymorphism is more frequent and associated with aggressive breast tumors with increased ANRIL and decreased p16INK4A expression

Chromosome position 9p21 encodes three-tumor suppressors p16INK4a, p14ARF, and p15INK4b, and the long non-coding RNA ANRIL (antisense noncoding RNA in the INK4 locus). The rs11515 single nucleotide polymorphism in the p16INK4a/p14ARF 3′ untranslated region is associated with glioblastoma, melanoma,...

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Bibliographic Details
Main Authors: Tania Lee Slatter, Janice Anne Royds, Anna ePilbrow, Antonio eAhn, Helen eMorrin, Chris eFramptom, I. Alasdair eRussell, Christine Schomisch Moravec, Wendy eSweet, W. H. Wilson eTang, Margaret Jane Currie, Noelyn Anne Hung
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-01-01
Series:Frontiers in Oncology
Subjects:
breast cancer
Single nucleotide polymorphisms
ANRIL
p16INK4a
9p21
rs11515
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00306/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00306/full

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