Development of a Human Cytomegalovirus (HCMV)-Based Therapeutic Cancer Vaccine Uncovers a Previously Unsuspected Viral Block of MHC Class I Antigen Presentation

Development of a Human Cytomegalovirus (HCMV)-Based Therapeutic Cancer Vaccine Uncovers a Previously Unsuspected Viral Block of MHC Class I Antigen Presentation

Human cytomegalovirus (HCMV) induces a uniquely high frequency of virus-specific effector/memory CD8+ T-cells, a phenomenon termed “memory inflation”. Thus, HCMV-based vaccines are particularly interesting in order to stimulate a sustained and strong cellular immune response against cancer. Glioblas...

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Bibliographic Details
Main Authors: Mohammed O. Abdelaziz, Sophia Ossmann, Andreas M. Kaufmann, Judith Leitner, Peter Steinberger, Gerald Willimsky, Martin J. Raftery, Günther Schönrich
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Immunology
Subjects:
human cytomegalovirus
therapeutic cancer vaccine
glioblastoma
cancer immunotherapy
viral immune evasion
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01776/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01776/full

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