Identification of roles for H264, H306, H439, and H635 in acid-dependent lipoprotein release by the LDL receptor

Lipoproteins internalized by the LDL receptor (LDLR) are released from this receptor in endosomes through a process that involves acid-dependent conformational changes in the receptor ectodomain. How acidic pH promotes this release process is not well understood. Here, we assessed roles for six hist...

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Bibliographic Details
Main Authors: Hongyun Dong, Zhenze Zhao, Drake G. LeBrun, Peter Michaely
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:Journal of Lipid Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520314176