Effects of chronic inhibition of phosphodiesterase-4D on behavior and regional rates of cerebral protein synthesis in a mouse model of fragile X syndrome

Effects of chronic inhibition of phosphodiesterase-4D on behavior and regional rates of cerebral protein synthesis in a mouse model of fragile X syndrome

Fragile X Syndrome (FXS) is caused by silencing the FMR1 gene which results in intellectual disability, hyperactivity, sensory hypersensitivity, autistic-like behavior, and susceptibility to seizures. This X-linked disorder is also associated with reduced cAMP levels in humans as well as animal mode...

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Bibliographic Details
Main Authors: Michael Rosenheck, Carrie Sheeler, Rachel Michelle Saré, Mark E. Gurney, Carolyn Beebe Smith
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Neurobiology of Disease
Subjects:
Fragile X syndrome
Fmr1 knockout mouse
Phosphodiesterase-4D
cAMP
Social behavior
Sleep
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996121002345

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http://www.sciencedirect.com/science/article/pii/S0969996121002345

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