Complement-dependent bystander injury to neurons in AQP4-IgG seropositive neuromyelitis optica

Complement-dependent bystander injury to neurons in AQP4-IgG seropositive neuromyelitis optica

Abstract Background Aquaporin-4-immunoglobulin G (AQP4-IgG) seropositive neuromyelitis optica spectrum disorder (herein called NMO) is an autoimmune disease of the central nervous system in which AQP4-IgG binding to AQP4 on astrocytes results in complement-dependent astrocyte injury and secondary in...

Full description

Bibliographic Details
Main Authors: Tianjiao Duan, Alex J. Smith, Alan S. Verkman
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Journal of Neuroinflammation
Subjects:
NMO
Aquaporin-4
Astrocyte
Neuron
Complement
Online Access:http://link.springer.com/article/10.1186/s12974-018-1333-z

Internet

http://link.springer.com/article/10.1186/s12974-018-1333-z

Similar Items