XPO1-dependent nuclear export as a target for cancer therapy

XPO1-dependent nuclear export as a target for cancer therapy

Abstract Cellular homeostasis requires the proper nuclear-cytoplasmic partitioning of large molecules, which is often deregulated in cancer. XPO1 is an export receptor responsible for the nuclear-cytoplasmic transport of hundreds of proteins and multiple RNA species. XPO1 is frequently overexpressed...

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Bibliographic Details
Main Authors: Nancy G. Azizian, Yulin Li
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Journal of Hematology & Oncology
Subjects:
XPO1
CRM1
Nuclear export
Selective inhibitor of nuclear export (SINE)
Selinexor
Cancer
Online Access:http://link.springer.com/article/10.1186/s13045-020-00903-4

Internet

http://link.springer.com/article/10.1186/s13045-020-00903-4

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