VPA does not enhance platinum binding to DNA in cisplatin-resistant neuroblastoma cancer cells

Neuroblastoma represents a malignancy of the sympathetic nervous system characteristic by biological heterogeneity. Thus, chemotherapy exhibits only low effectivity in curing high-risk forms. Previous studies revealed the cytotoxic potential of valproate on neuroblastoma cells. Nevertheless, these s...

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Bibliographic Details
Main Authors: Martina Raudenska, Ludmila Krejcova, Lukas Richtera, Zbynek Heger, Jan Hrabeta, Tomas Eckschlager, Marie Stiborova, Vojtech Adam, Monika Kratochvilova, Michal Masarik, Jaromir Gumulec
Format: Article
Language:English
Published: IOS Press 2017-09-01
Series:Tumor Biology
Online Access:https://doi.org/10.1177/1010428317711656