Targeting glycosylation of PD-1 to enhance CAR-T cell cytotoxicity

Targeting glycosylation of PD-1 to enhance CAR-T cell cytotoxicity

Abstract Asparagine-linked (N-linked) glycosylation is ubiquitous and can stabilize immune inhibitory PD-1 protein. Reducing N-linked glycosylation of PD-1 may decrease PD-1 expression and relieve its inhibitory effects on CAR-T cells. Considering that the codon of Asparagine is aac or aat, we wonde...

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Bibliographic Details
Main Authors: Xiaojuan Shi, Daiqun Zhang, Feng Li, Zhen Zhang, Shumin Wang, Yujing Xuan, Yu Ping, Yi Zhang
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Journal of Hematology & Oncology
Subjects:
Glycosylation
Single base editing
CAR-T cell
PD-1
Online Access:https://doi.org/10.1186/s13045-019-0831-5

Internet

https://doi.org/10.1186/s13045-019-0831-5

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