Free fatty acid release from human breast cancer tissue inhibits cytotoxic T-lymphocyte-mediated killing

Immune-mediated antitumor activities confront a variety of tumor-mediated defense mechanisms. Here, we describe a new mechanism involving FFA that may allow breast cancer to evade immune clearance. We determined the IC50 at which unbound free fatty acids (FFAu) inhibit murine cytotoxic T-lymphocyte...

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Bibliographic Details
Main Authors: Alan M. Kleinfeld, Clifford Okada
Format: Article
Language:English
Published: Elsevier 2005-09-01
Series:Journal of Lipid Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752032945X