Role of tumor suppressor p53 and micro-RNA interplay in multiple myeloma pathogenesis

Abstract The molecular mechanisms underlying dysregulated wild type (wt) p53 in multiple myeloma (MM) have been subjects of intense investigation for years. Indeed, correlation of rarely occurring TP53 gene mutations or deletions with adverse clinical outcomes in MM patients is strongly established,...

Full description

Bibliographic Details
Main Authors: Jahangir Abdi, Nasrin Rastgoo, Lihong Li, Wenming Chen, Hong Chang
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Journal of Hematology & Oncology
Subjects:
p53
Online Access:http://link.springer.com/article/10.1186/s13045-017-0538-4