Identification and clinical impact of potentially actionable somatic oncogenic mutations in solid tumor samples

Identification and clinical impact of potentially actionable somatic oncogenic mutations in solid tumor samples

Abstract Background An increasing number of anti-cancer therapeutic agents target specific mutant proteins that are expressed by many different tumor types. Successful use of these therapies is dependent on the presence or absence of somatic mutations within the patient’s tumor that can confer clini...

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Bibliographic Details
Main Authors: Sinead Toomey, Aoife Carr, Mateusz Janusz Mezynski, Yasir Elamin, Shereen Rafee, Mattia Cremona, Clare Morgan, Stephen Madden, Khairun I. Abdul-Jalil, Kathy Gately, Angela Farrelly, Elaine W. Kay, Susan Kennedy, Kenneth O’Byrne, Liam Grogan, Oscar Breathnach, Patrick G. Morris, Alexander J. Eustace, Joanna Fay, Robert Cummins, Anthony O’Grady, Roshni Kalachand, Norma O’Donovan, Fergal Kelleher, Aine O’Reilly, Mark Doherty, John Crown, Bryan T. Hennessy
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Journal of Translational Medicine
Online Access:http://link.springer.com/article/10.1186/s12967-020-02273-4

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http://link.springer.com/article/10.1186/s12967-020-02273-4

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