Biocompatible nucleus-targeted graphene quantum dots for selective killing of cancer cells via DNA damage

Biocompatible nucleus-targeted graphene quantum dots for selective killing of cancer cells via DNA damage

Qi et al. develop nucleus targeting graphene quantum dots (GQDs) by modifying amine-functionalised GQDs with nucleus targeting TAT peptides. The resulting functionalised GQDs exhibit good biocompatibility, nucleus uptake, and cancer cell targeting. They can suppress growth of cancer cells by selecti...

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Main Authors: Lei Qi, Tonghe Pan, Liling Ou, Zhiqiang Ye, Chunlei Yu, Bijun Bao, Zixia Wu, Dayong Cao, Liming Dai
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-01713-1
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spelling doaj-b0a7ad99f02648159a7db7a5883046922021-02-21T12:27:21ZengNature Publishing GroupCommunications Biology2399-36422021-02-014111210.1038/s42003-021-01713-1Biocompatible nucleus-targeted graphene quantum dots for selective killing of cancer cells via DNA damageLei Qi0Tonghe Pan1Liling Ou2Zhiqiang Ye3Chunlei Yu4Bijun Bao5Zixia Wu6Dayong Cao7Liming Dai8State key Laboratory of Ophthalmology, Optometry and Visual Science, Institute of Advanced Materials for Nano-Bio Applications, School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical UniversityState key Laboratory of Ophthalmology, Optometry and Visual Science, Institute of Advanced Materials for Nano-Bio Applications, School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical UniversityState key Laboratory of Ophthalmology, Optometry and Visual Science, Institute of Advanced Materials for Nano-Bio Applications, School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical UniversityState key Laboratory of Ophthalmology, Optometry and Visual Science, Institute of Advanced Materials for Nano-Bio Applications, School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical UniversityState key Laboratory of Ophthalmology, Optometry and Visual Science, Institute of Advanced Materials for Nano-Bio Applications, School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical UniversityState key Laboratory of Ophthalmology, Optometry and Visual Science, Institute of Advanced Materials for Nano-Bio Applications, School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical UniversityState key Laboratory of Ophthalmology, Optometry and Visual Science, Institute of Advanced Materials for Nano-Bio Applications, School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical UniversityDepartment of General Surgery, The First Hospital of Qiqihar, Affiliated Qiqihar Hospital, Southern Medical UniversityAustralian Carbon Materials Centre (A-CMC), School of Chemical Engineering, University of New South WalesQi et al. develop nucleus targeting graphene quantum dots (GQDs) by modifying amine-functionalised GQDs with nucleus targeting TAT peptides. The resulting functionalised GQDs exhibit good biocompatibility, nucleus uptake, and cancer cell targeting. They can suppress growth of cancer cells by selectively inducing DNA damage.https://doi.org/10.1038/s42003-021-01713-1
collection DOAJ
language English
format Article
sources DOAJ
author Lei Qi
Tonghe Pan
Liling Ou
Zhiqiang Ye
Chunlei Yu
Bijun Bao
Zixia Wu
Dayong Cao
Liming Dai
spellingShingle Lei Qi
Tonghe Pan
Liling Ou
Zhiqiang Ye
Chunlei Yu
Bijun Bao
Zixia Wu
Dayong Cao
Liming Dai
Biocompatible nucleus-targeted graphene quantum dots for selective killing of cancer cells via DNA damage
Communications Biology
author_facet Lei Qi
Tonghe Pan
Liling Ou
Zhiqiang Ye
Chunlei Yu
Bijun Bao
Zixia Wu
Dayong Cao
Liming Dai
author_sort Lei Qi
title Biocompatible nucleus-targeted graphene quantum dots for selective killing of cancer cells via DNA damage
title_short Biocompatible nucleus-targeted graphene quantum dots for selective killing of cancer cells via DNA damage
title_full Biocompatible nucleus-targeted graphene quantum dots for selective killing of cancer cells via DNA damage
title_fullStr Biocompatible nucleus-targeted graphene quantum dots for selective killing of cancer cells via DNA damage
title_full_unstemmed Biocompatible nucleus-targeted graphene quantum dots for selective killing of cancer cells via DNA damage
title_sort biocompatible nucleus-targeted graphene quantum dots for selective killing of cancer cells via dna damage
publisher Nature Publishing Group
series Communications Biology
issn 2399-3642
publishDate 2021-02-01
description Qi et al. develop nucleus targeting graphene quantum dots (GQDs) by modifying amine-functionalised GQDs with nucleus targeting TAT peptides. The resulting functionalised GQDs exhibit good biocompatibility, nucleus uptake, and cancer cell targeting. They can suppress growth of cancer cells by selectively inducing DNA damage.
url https://doi.org/10.1038/s42003-021-01713-1
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AT tonghepan biocompatiblenucleustargetedgraphenequantumdotsforselectivekillingofcancercellsviadnadamage
AT lilingou biocompatiblenucleustargetedgraphenequantumdotsforselectivekillingofcancercellsviadnadamage
AT zhiqiangye biocompatiblenucleustargetedgraphenequantumdotsforselectivekillingofcancercellsviadnadamage
AT chunleiyu biocompatiblenucleustargetedgraphenequantumdotsforselectivekillingofcancercellsviadnadamage
AT bijunbao biocompatiblenucleustargetedgraphenequantumdotsforselectivekillingofcancercellsviadnadamage
AT zixiawu biocompatiblenucleustargetedgraphenequantumdotsforselectivekillingofcancercellsviadnadamage
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AT limingdai biocompatiblenucleustargetedgraphenequantumdotsforselectivekillingofcancercellsviadnadamage
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