Inhibition of FOXO3 tumor suppressor function by betaTrCP1 through ubiquitin-mediated degradation in a tumor mouse model.

Inhibition of FOXO3 tumor suppressor function by betaTrCP1 through ubiquitin-mediated degradation in a tumor mouse model.

<h4>Background</h4>The ubiquitin-proteasome system is the primary proteolysis machine for controlling protein stability of the majority of regulatory proteins including those that are critical for cancer development. The forkhead box transcription factor FOXO3 plays a key role in regulat...

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Bibliographic Details
Main Authors: Wen-Bin Tsai, Young Min Chung, Yiyu Zou, See-Hyoung Park, Zhaohui Xu, Keiko Nakayama, Sue-Hwa Lin, Mickey C-T Hu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-07-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20625400/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20625400/?tool=EBI

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