Synthesis, Biological Evaluation and Molecular Docking of Novel Indole-Aminoquinazoline Hybrids for Anticancer Properties

Synthesis, Biological Evaluation and Molecular Docking of Novel Indole-Aminoquinazoline Hybrids for Anticancer Properties

A series of indole-aminoquinazolines was prepared via amination of the 2-aryl-4-chloroquinazolines with the 7-amino-2-aryl-5-bromoindoles. It was then evaluated for cytotoxicity in vitro against human lung cancer (A549), epithelial colorectal adenocarcinoma (Caco-2), hepatocellular carcinoma (C3A),...

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Bibliographic Details
Main Authors: Malose J. Mphahlele, Mmakwena M. Mmonwa, Abimbola Aro, Lyndy J. McGaw, Yee Siew Choong
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:International Journal of Molecular Sciences
Subjects:
indole-aminoquinazolines
cytotoxicity
apoptosis
EGFR-TK
molecular docking
Online Access:http://www.mdpi.com/1422-0067/19/8/2232

Internet

http://www.mdpi.com/1422-0067/19/8/2232

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