Inhibition of Lipid Accumulation in Skeletal Muscle and Liver Cells: A Protective Mechanism of Bilirubin Against Diabetes Mellitus Type 2

Inhibition of Lipid Accumulation in Skeletal Muscle and Liver Cells: A Protective Mechanism of Bilirubin Against Diabetes Mellitus Type 2

Ectopic lipid accumulation in skeletal muscle and liver drives the pathogenesis of diabetes mellitus type 2 (DMT2). Mild hyperbilirubinaemia has been repeatedly suggested to play a role in the prevention of DMT2 and is known for its capacity to shape an improved lipid phenotype in humans and in anim...

Full description

Bibliographic Details
Main Authors: Claudia A. Hana, Eva-Maria Klebermass, Theresa Balber, Markus Mitterhauser, Ruth Quint, Yvonne Hirtl, Antonia Klimpke, Sophie Somloi, Juliana Hutz, Elisabeth Sperr, Paulina Eder, Jana Jašprová, Petra Valášková, Libor Vítek, Elke Heiss, Karl-Heinz Wagner
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Pharmacology
Subjects:
bilirubin
mild hyperbilirubinaemia
ectopic lipid accumulation
C2C12 skeletal muscle cells
HepG2 cells
[18F]FDG uptake
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.636533/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.636533/full

Similar Items