Inhibition of Lipid Accumulation in Skeletal Muscle and Liver Cells: A Protective Mechanism of Bilirubin Against Diabetes Mellitus Type 2

Inhibition of Lipid Accumulation in Skeletal Muscle and Liver Cells: A Protective Mechanism of Bilirubin Against Diabetes Mellitus Type 2

Ectopic lipid accumulation in skeletal muscle and liver drives the pathogenesis of diabetes mellitus type 2 (DMT2). Mild hyperbilirubinaemia has been repeatedly suggested to play a role in the prevention of DMT2 and is known for its capacity to shape an improved lipid phenotype in humans and in anim...

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Bibliographic Details
Main Authors:	Claudia A. Hana, Eva-Maria Klebermass, Theresa Balber, Markus Mitterhauser, Ruth Quint, Yvonne Hirtl, Antonia Klimpke, Sophie Somloi, Juliana Hutz, Elisabeth Sperr, Paulina Eder, Jana Jašprová, Petra Valášková, Libor Vítek, Elke Heiss, Karl-Heinz Wagner
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-01-01
Series:	Frontiers in Pharmacology
Subjects:	bilirubin mild hyperbilirubinaemia ectopic lipid accumulation C2C12 skeletal muscle cells HepG2 cells [18F]FDG uptake
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2020.636533/full

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