Live axonal transport disruption by mutant huntingtin fragments in Drosophila motor neuron axons

Live axonal transport disruption by mutant huntingtin fragments in Drosophila motor neuron axons

Huntington's Disease is a neurodegenerative condition caused by a polyglutamine expansion in the huntingtin (Htt) protein, which aggregates and also causes neuronal dysfunction. Pathogenic N-terminal htt fragments perturb axonal transport in vitro. To determine whether this occurs in vivo and t...

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Bibliographic Details
Main Authors: C. Sinadinos, T. Burbidge-King, D. Soh, L.M. Thompson, J.L. Marsh, A. Wyttenbach, A.K. Mudher
Format: Article
Language:English
Published: Elsevier 2009-05-01
Series:Neurobiology of Disease
Subjects:
Huntington's Disease
N-terminal huntingtin
Drosophila
Motor neurons
Axonal transport
neuropeptide-Y
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109000424

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http://www.sciencedirect.com/science/article/pii/S0969996109000424

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