How a Mutation that Slows Aging Can Also Disproportionately Extend End-of-Life Decrepitude

Summary: The goal of aging research is to extend healthy, active life. For decades, C. elegans daf-2 insulin/insulin-like growth factor 1 (IGF-1) receptor mutants have served as a model for extended lifespan and youthfulness. However, a recent report suggested that their longevity is associated with...

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Bibliographic Details
Main Authors: Katie Podshivalova, Rex A. Kerr, Cynthia Kenyon
Format: Article
Language:English
Published: Elsevier 2017-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717304230