Engineering hiPSC-CM and hiPSC-EC laden 3D nanofibrous splenic hydrogel for improving cardiac function through revascularization and remuscularization in infarcted heart

Engineering hiPSC-CM and hiPSC-EC laden 3D nanofibrous splenic hydrogel for improving cardiac function through revascularization and remuscularization in infarcted heart

Cell therapy has been a promising strategy for cardiac repair after myocardial infarction (MI), but a poor ischemic environment and low cell delivery efficiency remain significant challenges. The spleen serves as a hematopoietic stem cell niche and secretes cardioprotective factors after MI, but it...

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Bibliographic Details
Main Authors: Ge Guan, Da Huo, Yanzhao Li, Xiaolin Zhao, Yinghao Li, Zhongliang Qin, Dayu Sun, Guanyuan Yang, Mingcan Yang, Ju Tan, Wen Zeng, Chuhong Zhu
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2021-12-01
Series:Bioactive Materials
Subjects:
Stem cell-laden splenic hydrogel
hiPSC differentiation platform
Antioxidant stress
Myocardial infarction
Cardiac repair
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X21001766

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http://www.sciencedirect.com/science/article/pii/S2452199X21001766

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