The Overcrowded Crossroads: Mitochondria, Alpha-Synuclein, and the Endo-Lysosomal System Interaction in Parkinson’s Disease

The Overcrowded Crossroads: Mitochondria, Alpha-Synuclein, and the Endo-Lysosomal System Interaction in Parkinson’s Disease

Parkinson’s disease (PD) is the second most common neurodegenerative disorder worldwide, mainly affecting the elderly. The disease progresses gradually, with core motor presentations and a multitude of non-motor manifestations. There are two neuropathological hallmarks of PD, the dopaminer...

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Bibliographic Details
Main Authors: Kai-Jung Lin, Kai-Lieh Lin, Shang-Der Chen, Chia-Wei Liou, Yao-Chung Chuang, Hung-Yu Lin, Tsu-Kung Lin
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:International Journal of Molecular Sciences
Subjects:
parkinson’s disease
lewy body
mitochondria
mitophagy
α-synuclein
lysosome
Online Access:https://www.mdpi.com/1422-0067/20/21/5312

Internet

https://www.mdpi.com/1422-0067/20/21/5312

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