Prognostic significance of SOCS1 and SOCS3 tumor suppressors and oncogenic signaling pathway genes in hepatocellular carcinoma

Prognostic significance of SOCS1 and SOCS3 tumor suppressors and oncogenic signaling pathway genes in hepatocellular carcinoma

Abstract Background SOCS1 and SOCS3 genes are considered tumor suppressors in hepatocellular carcinoma (HCC) due to frequent epigenetic repression. Consistent with this notion, mice lacking SOCS1 or SOCS3 show increased susceptibility to diethylnitrosamine (DEN)-induced HCC. As SOCS1 and SOCS3 are i...

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Bibliographic Details
Main Authors: Md Gulam Musawwir Khan, Amit Ghosh, Bhavesh Variya, Madanraj Appiya Santharam, Awais Ullah Ihsan, Sheela Ramanathan, Subburaj Ilangumaran
Format: Article
Language:English
Published: BMC 2020-08-01
Series:BMC Cancer
Subjects:
Hepatocellular carcinoma
SOCS1
SOCS3
TCGA
Tumor suppressor
Oncogenic signalling
Online Access:http://link.springer.com/article/10.1186/s12885-020-07285-3

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http://link.springer.com/article/10.1186/s12885-020-07285-3

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