In vivo magnetic resonance studies reveal neuroanatomical and neurochemical abnormalities in the serine racemase knockout mouse model of schizophrenia

In vivo magnetic resonance studies reveal neuroanatomical and neurochemical abnormalities in the serine racemase knockout mouse model of schizophrenia

Background: Decreased availability of the N-methyl-d-aspartate receptor (NMDAR) co-agonist d-serine is thought to promote NMDAR hypofunction and contribute to the pathophysiology of schizophrenia, including neuroanatomical abnormalities, such as cortical atrophy and ventricular enlargement, and neur...

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Bibliographic Details
Main Authors: Matthew D. Puhl, Dionyssios Mintzopoulos, J. Eric Jensen, Timothy E. Gillis, Glenn T. Konopaske, Marc J. Kaufman, Joseph T. Coyle
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Neurobiology of Disease
Subjects:
γ-Aminobutyric acid
Glutamate
Magnetic resonance imaging
Magnetic resonance spectroscopy
Schizophrenia
Serine racemase knockout mouse
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114003027

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http://www.sciencedirect.com/science/article/pii/S0969996114003027

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