Collateral Damage Intended—Cancer-Associated Fibroblasts and Vasculature Are Potential Targets in Cancer Therapy

Collateral Damage Intended—Cancer-Associated Fibroblasts and Vasculature Are Potential Targets in Cancer Therapy

After oncogenic transformation, tumor cells rewire their metabolism to obtain sufficient energy and biochemical building blocks for cell proliferation, even under hypoxic conditions. Glucose and glutamine become their major limiting nutritional demands. Instead of being autonomous, tumor cells chang...

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Bibliographic Details
Main Authors: Ana Cavaco, Maryam Rezaei, Stephan Niland, Johannes A. Eble
Format: Article
Language:English
Published: MDPI AG 2017-11-01
Series:International Journal of Molecular Sciences
Subjects:
abnormal tumor vasculature
anti-angiogenesis
cancer-associated fibroblasts
endothelial cell–tumor cell interaction
targeted tumor therapy
tumor neovascularization
tumor metabolism
tumor stroma
tumor vessel disruption
vasculogenic mimicry
Online Access:https://www.mdpi.com/1422-0067/18/11/2355

Internet

https://www.mdpi.com/1422-0067/18/11/2355

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