MR1-Restricted T Cells Are Unprecedented Cancer Fighters

MR1-Restricted T Cells Are Unprecedented Cancer Fighters

Non-polymorphic MHC class I-related molecule MR1 presents antigenic bacterial metabolites to mucosal-associated invariant T (MAIT) cells and self-antigens to MR1-restricted T (MR1T) cells. Both MR1-restricted T cell populations are readily identified in healthy individuals, with MAIT cells accountin...

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Bibliographic Details
Main Authors: Alessandro Vacchini, Andrew Chancellor, Julian Spagnuolo, Lucia Mori, Gennaro De Libero
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Immunology
Subjects:
MR1
MR1T
self-antigens
tumor recognition
T-cell therapy
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00751/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00751/full

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