Frequent epigenetic silencing of the folate-metabolising gene cystathionine-beta-synthase in gastrointestinal cancer.

Frequent epigenetic silencing of the folate-metabolising gene cystathionine-beta-synthase in gastrointestinal cancer.

Both gastric and colorectal cancers (CRC) are the most frequently occurring malignancies worldwide with the overall survival of these patients remains unsatisfied. Identification of tumor suppressor genes (TSG) silenced by promoter CpG methylation uncovers mechanisms of tumorigenesis and identifies...

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Bibliographic Details
Main Authors: Hong Zhao, Qinshan Li, Jian Wang, Xianwei Su, Ka Man Ng, Tian Qiu, Ling Shan, Yun Ling, Linfang Wang, Jianqiang Cai, Jianming Ying
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3496708?pdf=render

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http://europepmc.org/articles/PMC3496708?pdf=render

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