Activation-induced Markers Detect Vaccine-Specific CD4+ T Cell Responses Not Measured by Assays Conventionally Used in Clinical Trials

Activation-induced Markers Detect Vaccine-Specific CD4+ T Cell Responses Not Measured by Assays Conventionally Used in Clinical Trials

Immunogenicity of T cell-inducing vaccines, such as viral vectors or DNA vaccines and Bacillus Calmette-Guérin (BCG), are frequently assessed by cytokine-based approaches. While these are sensitive methods that have shown correlates of protection in various vaccine studies, they only identify a smal...

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Bibliographic Details
Main Authors: Georgina Bowyer, Tommy Rampling, Jonathan Powlson, Richard Morter, Daniel Wright, Adrian V.S. Hill, Katie J. Ewer
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Vaccines
Subjects:
vaccines
activation-induced markers
antigen-specific T cells
viral vector
adenovirus
modified vaccinia virus Ankara
Ebola
Online Access:http://www.mdpi.com/2076-393X/6/3/50

Internet

http://www.mdpi.com/2076-393X/6/3/50

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