Malignant transformation of oral leukoplakia is associated with macrophage polarization

Malignant transformation of oral leukoplakia is associated with macrophage polarization

Abstract Background Most oral squamous cell carcinomas (OSCC) occur on the basis of oral leukoplakias (OLP). The histologic degree of dysplasia is insufficient for the prediction of OLP malignant transformation. Immunologic parameters are gaining importance for prognostic assessment and therapy of c...

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Bibliographic Details
Main Authors: Manuel Weber, Falk Wehrhan, Christoph Baran, Abbas Agaimy, Maike Büttner-Herold, Hatice Öztürk, Kristina Neubauer, Claudia Wickenhauser, Marco Kesting, Jutta Ries
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Journal of Translational Medicine
Subjects:
Macrophage polarization
Oral leukoplakia
M1
M2
CD68
CD163
Online Access:https://doi.org/10.1186/s12967-019-02191-0

Internet

https://doi.org/10.1186/s12967-019-02191-0

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