Hot Spot TERT Promoter Mutations Are Rare in Sporadic Pancreatic Neuroendocrine Neoplasms and Associated with Telomere Length and Epigenetic Expression Patterns

Hot Spot TERT Promoter Mutations Are Rare in Sporadic Pancreatic Neuroendocrine Neoplasms and Associated with Telomere Length and Epigenetic Expression Patterns

Cancer cells activate a telomere maintenance mechanism like telomerase in order to proliferate indefinitely. Telomerase can be reactivated by gain-of-function Telomerase Reverse Transcriptase (TERT) promoter mutations (TPMs) that occur in several cancer subtypes with high incidence and association w...

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Bibliographic Details
Main Authors: Alexandra Posch, Sarah Hofer-Zeni, Eckhard Klieser, Florian Primavesi, Elisabeth Naderlinger, Anita Brandstetter, Martin Filipits, Romana Urbas, Stefan Swiercynski, Tarkan Jäger, Paul Winkelmann, Tobias Kiesslich, Lingeng Lu, Daniel Neureiter, Stefan Stättner, Klaus Holzmann
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Cancers
Subjects:
pancreatic neuroendocrine tumor
TERT promoter mutation
telomere length
tumor heterogeneity
pyrosequencing
microRNA
Online Access:https://www.mdpi.com/2072-6694/12/6/1625

Internet

https://www.mdpi.com/2072-6694/12/6/1625

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