Parallel Synthesis of Peptide-Like Macrocycles Containing Imidazole-4,5-dicarboxylic Acid

Parallel Synthesis of Peptide-Like Macrocycles Containing Imidazole-4,5-dicarboxylic Acid

We prepared a series of peptide-like 14-membered macrocycles containing an imidazole-4,5-dicarboxylic acid scaffold by using known coupling reagents and protecting group strategies. Yields of the purified macrocycles were poor on average, yet seemingly independent of amino acid substitution or stere...

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Bibliographic Details
Main Authors: Paul W. Baures, Kraig A. Wheeler, Zhigang Xu
Format: Article
Language:English
Published: MDPI AG 2012-05-01
Series:Molecules
Subjects:
macrocycle
scaffold
library synthesis
imidazole-4,5-dicarboxylic acid
Online Access:http://www.mdpi.com/1420-3049/17/5/5346

Internet

http://www.mdpi.com/1420-3049/17/5/5346

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