Caspase-8 Inhibition Prevents the Cleavage and Degradation of E3 Ligase Substrate Receptor Cereblon and Potentiates Its Biological Function

Caspase-8 Inhibition Prevents the Cleavage and Degradation of E3 Ligase Substrate Receptor Cereblon and Potentiates Its Biological Function

Cereblon (CRBN), a substrate receptor of cullin 4-RING E3 ligase (CRL4), mediates the ubiquitination and degradation of constitutive substrates and immunomodulatory drug-induced neo-substrates including MEIS2, c-Jun, CLC1, IKZF1/3, CK1α, and SALL4. It has been reported that CRBN itself could be degr...

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Bibliographic Details
Main Authors: Liang Zhou, Wenjun Yu, David S. Jayabalan, Ruben Niesvizky, Samie R. Jaffrey, Xiangao Huang, Guoqiang Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
cereblon
caspase-8
cleavage
TRAIL
multiple myeloma
lenalidomide
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.605989/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2020.605989/full

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