pTyr421 cortactin is overexpressed in colon cancer and is dephosphorylated by curcumin: involvement of non-receptor type 1 protein tyrosine phosphatase (PTPN1).

pTyr421 cortactin is overexpressed in colon cancer and is dephosphorylated by curcumin: involvement of non-receptor type 1 protein tyrosine phosphatase (PTPN1).

Cortactin (CTTN), first identified as a major substrate of the Src tyrosine kinase, actively participates in branching F-actin assembly and in cell motility and invasion. CTTN gene is amplified and its protein is overexpressed in several types of cancer. The phosphorylated form of cortactin (pTyr(42...

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Main Authors: Vijayababu M Radhakrishnan, Pawel Kojs, Gavin Young, Rajalakshmy Ramalingam, Bhumasamudram Jagadish, Eugene A Mash, Jesse D Martinez, Fayez K Ghishan, Pawel R Kiela
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3899080?pdf=render

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http://europepmc.org/articles/PMC3899080?pdf=render

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