Minimal hepatic glucose-6-phosphatase-α activity required to sustain survival and prevent hepatocellular adenoma formation in murine glycogen storage disease type Ia

Minimal hepatic glucose-6-phosphatase-α activity required to sustain survival and prevent hepatocellular adenoma formation in murine glycogen storage disease type Ia

Glycogen storage disease type Ia (GSD-Ia), characterized by impaired glucose homeostasis and chronic risk of hepatocellular adenoma (HCA), is caused by a deficiency in glucose-6-phosphatase-α (G6Pase-α or G6PC) activity. In a previous 70–90 week-study, we showed that a recombinant adeno-associated v...

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Bibliographic Details
Main Authors: Young Mok Lee, Goo-Young Kim, Chi-Jiunn Pan, Brian C. Mansfield, Janice Y. Chou
Format: Article
Language:English
Published: Elsevier 2015-06-01
Series:Molecular Genetics and Metabolism Reports
Subjects:
Gene therapy
Recombinant adeno-associated virus vector
Glucose homeostasis
Glucose-6-phosphate transporter
Online Access:http://www.sciencedirect.com/science/article/pii/S2214426915000129

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http://www.sciencedirect.com/science/article/pii/S2214426915000129

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