The protective effect of the EP2 receptor on TGF-β1 induced podocyte injury via the PI3K / Akt signaling pathway.

The protective effect of the EP2 receptor on TGF-β1 induced podocyte injury via the PI3K / Akt signaling pathway.

Transforming growth factor β1 (TGF-β1) plays a central role in chronic kidney diseases. TGF-β1 induction causes podocyte injury, which results in proteinuria and renal failure. However, the effect of the prostaglandin E2 /E-prostanoid receptor (EP2) on TGF-β1-induced podocyte injury remains unknown....

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Bibliographic Details
Main Authors: Jing Liu, Yi-de Zhang, Xiao-Lan Chen, Xue-Ling Zhu, Xu Chen, Jian-Hua Wu, Nai-Feng Guo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5945042?pdf=render

Internet

http://europepmc.org/articles/PMC5945042?pdf=render

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