Frequencies of 23 functionally significant variant alleles related with metabolism of antineoplastic drugs in the Chilean population: comparison with Caucasian and Asian populations

Frequencies of 23 functionally significant variant alleles related with metabolism of antineoplastic drugs in the Chilean population: comparison with Caucasian and Asian populations

Cancer is a leading cause of death worldwide. The cancer incidence rate in Chile is 133.7/100,000 inhabitants and it is the second cause of death, after cardiovascular diseases. Most of the antineoplastic drugs are metabolized to be detoxified, and some of them to be activated. Genetic polymorphisms...

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Bibliographic Details
Main Authors: Angela Margarita Roco, Luis Abel Quiñones, José A G Agúndez, Elena eGarcía-Martín, Valentina eSquicciarini, Carla Estefania Miranda, Joselyn eGaray, Nancy eFarfán, Iván Nicolás Saavedra, Dante Daniel Caceres, Carol eIbarra, Nelson Miguel Varela
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-11-01
Series:Frontiers in Genetics
Subjects:
biomarkers
polymorphisms
MTHFR
Pharmacogenetics and pharmacogenomics
CYP450
Antineoplastic
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00229/full

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http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00229/full

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