Combined genetic and chemical screens indicate protective potential for EGFR inhibition to cardiomyocytes under hypoxia

Abstract The return of blood flow to ischemic heart after myocardial infarction causes ischemia–reperfusion injury. There is a clinical need for novel therapeutic targets to treat myocardial ischemia–reperfusion injury. Here we screened for targets for the treatment of ischemia–reperfusion injury us...

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Bibliographic Details
Main Authors: Juho Heliste, Anne Jokilammi, Katri Vaparanta, Ilkka Paatero, Klaus Elenius
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-96033-z