A Serial shRNA Screen for Roadblocks to Reprogramming Identifies the Protein Modifier SUMO2

A Serial shRNA Screen for Roadblocks to Reprogramming Identifies the Protein Modifier SUMO2

The generation of induced pluripotent stem cells (iPSCs) from differentiated cells following forced expression of OCT4, KLF4, SOX2, and C-MYC (OKSM) is slow and inefficient, suggesting that transcription factors have to overcome somatic barriers that resist cell fate change. Here, we performed an un...

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Bibliographic Details
Main Authors: Marti Borkent, Brian D. Bennett, Brad Lackford, Ori Bar-Nur, Justin Brumbaugh, Li Wang, Ying Du, David C. Fargo, Effie Apostolou, Sihem Cheloufi, Nimet Maherali, Stephen J. Elledge, Guang Hu, Konrad Hochedlinger
Format: Article
Language:English
Published: Elsevier 2016-05-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671116000552

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http://www.sciencedirect.com/science/article/pii/S2213671116000552

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