Lovastatin Alleviates α-Synuclein Aggregation and Phosphorylation in Cellular Models of Synucleinopathy

Lovastatin Alleviates α-Synuclein Aggregation and Phosphorylation in Cellular Models of Synucleinopathy

Parkinson’s disease (PD) is one of the most common neurodegenerative diseases. Pathologically, it is characterized by the aberrant aggregation of α-synuclein (α-syn) in neurons. Clinical evidence shows that patients with hypercholesterolemia are more likely to get PD, while lovastatin users have a l...

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Bibliographic Details
Main Authors: Lijun Dai, Jiannan Wang, Mingyang He, Min Xiong, Ye Tian, Chaoyang Liu, Zhentao Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Parkinson’s disease
protein aggregation
α-synuclein
statins
casein kinase 2
haistone acetylation
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2021.682320/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2021.682320/full

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