The Effect of Cofactor Binding on the Conformational Plasticity of the Biological Receptors in Artificial Metalloenzymes: The Case Study of LmrR

The Effect of Cofactor Binding on the Conformational Plasticity of the Biological Receptors in Artificial Metalloenzymes: The Case Study of LmrR

The design of Artificial Metalloenzymes (ArMs), which result from the incorporation of organometallic cofactors into biological structures, has grown steadily in the last two decades and important new-to-Nature reactions have been reached. These type of exercises could greatly benefit from an unders...

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Bibliographic Details
Main Authors: Lur Alonso-Cotchico, Jaime Rodríguez-Guerra Pedregal, Agustí Lledós, Jean-Didier Maréchal
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Chemistry
Subjects:
molecular modeling
artificial metalloenzymes
molecular dynamics
interactive analysis
cofactor binding
molecular plasticity
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2019.00211/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2019.00211/full

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